2003 Elder DandaBy: Caroline Danda, PhD, Prairie Village, KS

Dr. Danda is the recipient of the IFFGD 2003 Research Award to Pediatric Investigator, Clinical Science.

Dr. Danda's research projects include examining the physiological and psychosocial factors associated with functional dyspepsia and examining the effectiveness of several treatment protocols for children with functional dyspepsia; examining the effectiveness of noninvasive, educational treatment on the resolution of functional fecal retention; determining psychosocial and family factors related to initial treatment failures in functional fecal retention; and assessing whether fear increases anal sphincter pressures.

As many as 10–20% of school-age children experience bellyaches severe enough to affect activities. Not all of these children seek medical treatment or experience chronic, continuous abdominal pain. A subset of children present to their clinician with symptoms sufficient to meet criteria for a functional gastrointestinal disorder (e.g., functional dyspepsia, irritable bowel syndrome). Past research on childhood abdominal pain used a broad description – recurrent abdominal pain (RAP).

Rome II criteria, however, classifies abdominal pain into subsets based on symptom presentation. My research focuses on examining the psychosocial contributions to these functional gastrointestinal disorders and determining whether there are different psychosocial factors (e.g., emotional or behavioral symptoms, developmental stressors, family communication patterns) associated with the specific functional gastrointestinal disorders.

I am particularly interested in identifying factors that predispose children and adolescents with functional gastrointestinal disorders to experience disability and identifying psychosocial factors that affect treatment outcome. I am collaborating on a research project collecting data to provide a description of the developmental, psychosocial, and social factors influencing children with functional abdominal pain disorders and compare medical (e.g., drugs such as imipramine, montelukast, ranitidine**, and erythromycin) and psychological (e.g., cognitive behavioral therapy) treatment for functional dyspepsia.

In addition to comparing treatment modalities, we hope to identify factors associated with treatment outcome. Essentially, we want to find out which treatments work for which patients. Treatment of functional gastrointestinal disorders does not appear to be “one size fits all.”

Another core issue related to functional gastrointestinal disorders is disability. Some children experience interruption in their daily activities due to abdominal pain, whereas others do not. Which children experience disability related to a functional gastrointestinal disorder and what factors predispose them to experience disability?

Pain Associated Disability Syndrome (PADS) is a term used to describe patients who experience a downward spiral of disability (i.e., school absence, withdrawal from friends, restriction of daily activities) and pain for which acute pain management strategies have failed.

A retrospective analysis [examination of known outcomes using existing records] indicated that almost all patients with PADS had a functional gastrointestinal disorder as well as physical and emotional stressors that sustained pain and arousal. Pain and disability are exacerbated or maintained via medical, psychosocial, and developmental factors. For example, pain experiences can lead to an increased sensitivity to potentially painful stimuli (visceral hyperalgesia).

Undergoing multiple medical tests without explanation can lead to heightened anxiety and arousal. Developmental challenges, such as transitions to a new school, disruptions in a peer group, and puberty, can lead to heightened states of stress. Heightened states of stress and arousal, in turn, can exacerbate pain sensation and focus.

In collaboration with other team members here at the University of Kansas, I plan to systematically and prospectively define the characteristics of patients with PADS, examine the effects of multidisciplinary treatment, and identify factors associated with treatment outcome.

One area I plan to explore is the contribution of anxiety related to somatic symptoms and generalized anxiety or depression. Parents and children’s negative or worrisome thoughts about medical problems are likely to play a large role in the development of PADS.

For example, many children with a functional gastrointestinal disorder undergo multiple medical tests that result in negative results, which then increase anxiety, either in the patient and/or the parents. In addition, an anxiety or depressive disorder may lead to a predisposition to experience somatic symptoms, such as abdominal pain. Family dynamics and communication, especially during adolescent years, can also play a role in exacerbating and maintaining pain and disability.

Research on PADS patients will ultimately help provide information to diagnose and treat these youths more effectively.

Lastly, I am involved in several projects pertaining to Functional Fecal Retention (FFR), a common diagnosis associated with constipation that is characterized by at least 12 weeks of passage of large diameter stools at intervals less than two times a week; and retentive posturing (i.e., avoiding defecation by purposefully contracting the pelvic floor). Presumably, children with constipation experience pain with defecation of large, hard stools and develop a fear of defecation. Toilet learning is either failed or interrupted, and children appear unwilling or unable to relax the pelvic floor, creating an obstruction to defecation.

At the University of Kansas, we are examining whether fear actually increases anal sphincter pressure and whether imagery and relaxation reduce fear and anal sphincter pressure. Children are randomized to either no treatment or treatment involving learning relaxation and imagery. Physiological and visual analog readings of anxiety are taken before, during, and after colonic manometry catheter removal.

Another study involves piloting a developmentally friendly, educational, non-invasive treatment of FFR. FFR may often go unrecognized at first, and children may be subjected to invasive and painful procedures, including enemas and repeated rectal exams, that could increase fear of defecation.

The new approach to treatment includes education for the child and family about FFR, stool disimpaction with MiraLax, and assurance of painless defecation, as well as brief behavioral recommendations about differential attention to toileting behaviors (i.e., praising appropriate toileting and other positive behaviors while minimizing attention to problematic behaviors).

Goals of the study include determining the effect of this first, primarily educational visit on symptom resolution and identifying medical and psychosocial factors associated with treatment success and failure.

Children with encopresis, or fecal soiling, tend to have more behavioral and social problems than other children, although not necessarily at clinical levels. The question remains, however, what role does oppositional behavior, attention problems, anxiety, or depressive symptoms play in children with persistent FFR? If children have coexisting psychological problems, does treatment of these disorders lead to improvements in FFR?

Source: Adapted from IFFGD Publication Functional Gastrointestinal Disorders - Biopsychosocial Perspectives on Assessment and Treatment by Caroline Danda, PhD, Prairie Village, KS.

** Beginning September 2019, the US Food & Drug Administration (FDA) is alerting health care professionals and patients of specific recalls of ranitidine (Zantac). Find FDA details here

Research Awards
2020 Award Recipients
Kyle Staller, MD
Christopher V. Almario, MD
Maria Raffaella Barbaro, PhD
2019 Award Recipients
Arpana Gupta, PhD
David Levinthal, MD, PhD
Ilan Koppen, MD, PhD
2018 Award Recipients
Amaranath Karunanayake, PhD
Katja Kovacic, MD
Cristina Martinez, PhD
Ans Pauwels, PhD
2013 Award Recipients
Enrico Corazziari, MD
Jan Tack, MD, PhD
Report from Gary Mawe, PhD: The Roles of Intestinal Nerves and Serotonin in Gut Function and Dysfunction
Ashley Blackshaw, PhD
Carlo Di Lorenzo, MD
Niranga Manjuri Devanarayana, MD
Report from Lukas Van Oudenhove, PhD: Solving the Biopsychosocial Puzzle in Functional Dyspepsia
Muriel Larauche, PhD
2011 Award Recipients
Report from Ronnie Fass, MD: Sleep and Gastroesophageal Reflux Disease (GERD)
Million Mulugeta, PhD
Adrian Miranda, MD
Samuel Nurko, MD
Sudarshan Jadcherla, MD
Shaman Rajindrajith, MD
2009 Award Recipients
Satish Rao, MD
Emeran Mayer, MD
Javier Santos, MD
Report from Martin Storr, MD, PhD: Functional Gastrointestinal Disorders: New Insights in Enteric Regulation
Report From Miguel Saps, MD: Functional Abdominal Pain in Children and Adolescents
2007 Award Recipients
Report from Bruce D. Naliboff, PhD: Symptom Based Psychology for Functional Gastrointestinal Disorders
Report from Magnus Simrén, MD, PhD: Irritable Bowel Syndrome: Searching for Underlying Causes
Report from Brennan M. R. Spiegel, MD, MSHS: Diagnostic Testing in Irritable Bowel Syndrome: Theory vs. Reality
Report from Sylvie Bradesi, PhD: Role of the Central Immune System in Functional Disorders
Paul E. Hyman, MD
Report from Miranda A. L. van Tilburg, PhD: Home Based Guided Imagery to Treat Pediatric Functional Abdominal Pain
Report from Fernando Azpiroz, MD, PhD: Understanding Intestinal Gas
2005 Award Recipients
Report from Yvette Tache, PhD: Stress and Irritable Bowel Syndrome: Unraveling the Code
Report from Shaheen Hamdy, MRCP, PhD: Adult Neurogenic Dysphagia -- Disorders and Conditions that Disrupt Swallowing
Report from Michael A. Pezzone, MD, PhD: Chronic Pelvic Pain and the Overlap of Pelvic Pain Disorders
Report from Bridget R. Southwell, PhD: Research into Treatment-Resistant Constipation in Children
Report from Rachel Rosen, MD, MPH: Symptoms Arising from Non-Acid Reflux in Children
2003 Award Recipients
Report from William E. Whitehead, PhD: Summary of Clinical Research Activities
Jyoti N. Sengupta, PhD
Report from Caroline Elder Danda, PhD: Biopsychosocial Perspectives on Assessment and Treatment
Report from Terry Buchmiller-Crair, MD: Using the Fetal Gastrointestinal Tract to Overcome Neonatal Disease
Report from Dan L. Dumitrascu, MD, PhD: The Psychosocial Adjustment to Illness in Irritable Bowel Syndrome
Report from Klaus Bielefeldt, MD, PhD: Understanding Pain and Discomfort in Functional GI Disorders
Research Grants
IFFGD Competitive Grants
2014 IFFGD Idiopathic Gastroparesis Research Grants
Leo Cheng, PhD
Braden Kuo, MD, MSc
Richard McCallum, MD
2008 IFFGD Competitive Research Grants
IFFGD Noncompetitive Grants
Other Research Grant Opportunities
Funding Research
Need for Funding Research
How to Make a Difference
The State of Research at NIH & NIDDK
Clinical Trials & Studies
Guide to Randomized Clinical Trials
Clinical Trials and Studies

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