Cyclic vomiting syndrome (CVS) was first described about 120 years ago by Dr. Samuel Gee, the erudite British physician. Interest in the syndrome was revived when Kathleen Adams, a parent of an affected child founded the Cyclic Vomiting Syndrome Association in 1993. She enlisted the support of pediatric gastroenterologists, Drs. David Fleisher and B.U.K. Li, who recognized that better treatment of the disorder would only occur if the syndrome could be scientifically defined for medical researchers. This article describes CVS and approaches to treatment.