Award for Clinical Science Investigator

Head Shot 2020 Kyle Staller

Dr. Staller’s research interests include clinical and epidemiologic research in neurogastroenterology and motility with particular interest in chronic constipation, irritable bowel syndrome (IBS), fecal incontinence, eating disorders, and women’s health in functional GI diseases. His research has been published in medical journals across the spectrum of GI, and he also serves as a medical liaison to the media with appearances in national news outlets as well as health and wellness magazines.

Dr. Staller received his medical degree from Harvard Medical School and trained at Massachusetts General Hospital (MGH) for residency and gastroenterology (GI) fellowship. He also completed formal training in epidemiology culminating in a Masters of Public Health from the Harvard School of Public Health and subspecialty training in neurogastroenterology and motility at MGH before joining the faculty.

Kyle Staller, MD, MPH is a neurogastroenterologist with a clinical research program focusing on clinical and epidemiologic research in neurogastroenterology and motility, specifically the epidemiology of irritable bowel syndrome (IBS), chronic constipation, and fecal incontinence; early life risk factors for IBS, physiologic characterization of chronic constipation and bloating; and the biopsychosocial model of functional GI diseases.

He is currently using his training in epidemiology to understand and define the relationship between environmental predictors, such as diet and lifestyle factors and the fecal incontinence, utilizing large cohorts derived from the Nurse’s Health Study. He has already used these powerful cohorts to examine the relationship between obesity, physical activity, and dietary fiber intake and the risk of fecal incontinence. His examination of the role of menopausal hormone therapy and dietary fiber in the development of fecal incontinence has resulted in two first-author publications in Gastroenterology, and he also served as a coinvestigator on a R21 from the National Institutes of Health (NIH) on genetic susceptibilities for fecal incontinence. He has recently teamed up with Dr. Satish Rao from Augusta University and his mentor, Dr. Braden Kuo on a NIH R01-funded clinical trial investigating the effects of translumbosacral neuromodulation therapy for the treatment of fecal incontinence.

As one of the primary investigators in the neurogastroenterology group in the Nurses’ Health Study, he has been actively involved in the placement of relevant questions into follow up surveys from which potentially ground-breaking impacts on our understanding of constipation and irritable bowel syndrome are expected. He is currently working with one of his mentors, Dr. Andy Chan, to leverage prospective cohorts to better understand the biopsychosocial processes in adolescence underlying the emergence of IBS in adulthood, work which was funded by a career development award from the American Gastroenterological Association (Research Scholar Award).

Within MGH, he has been working to improve our understanding of the intersection of disordered eating and GI symptoms, creating a cohort of individuals with eating disorders in recovery to gain clinical, psychosocial, and translational insight into the pathogenesis of persistent GI symptoms in this often struggling patient group.

He is currently working with investigators from the Media Lab at the Massachusetts Institute of Technology on a project using artificial intelligence to gain insight into IBS and other functional GI diseases. By using patients’ own words describing their symptoms in conjunction with natural language processing, they are hoping to discover novel, patient-centered latent themes to more accurately diagnose and classify functional GI diseases among patients presenting for consultation and diagnostic endoscopy.

Clinical Science is the research approach aimed at understanding the diagnosis and treatment of diseases and disorders through studies involving people, usually carried out in clinical settings.

Research Awards
2020 Award Recipients
Kyle Staller, MD
Christopher V. Almario, MD
Maria Raffaella Barbaro, PhD
2019 Award Recipients
Arpana Gupta, PhD
David Levinthal, MD, PhD
Ilan Koppen, MD, PhD
2018 Award Recipients
Amaranath Karunanayake, PhD
Katja Kovacic, MD
Cristina Martinez, PhD
Ans Pauwels, PhD
2013 Award Recipients
Enrico Corazziari, MD
Jan Tack, MD, PhD
Report from Gary Mawe, PhD: The Roles of Intestinal Nerves and Serotonin in Gut Function and Dysfunction
Ashley Blackshaw, PhD
Carlo Di Lorenzo, MD
Niranga Manjuri Devanarayana, MD
Report from Lukas Van Oudenhove, PhD: Solving the Biopsychosocial Puzzle in Functional Dyspepsia
Muriel Larauche, PhD
2011 Award Recipients
Report from Ronnie Fass, MD: Sleep and Gastroesophageal Reflux Disease (GERD)
Million Mulugeta, PhD
Adrian Miranda, MD
Samuel Nurko, MD
Sudarshan Jadcherla, MD
Shaman Rajindrajith, MD
2009 Award Recipients
Satish Rao, MD
Emeran Mayer, MD
Javier Santos, MD
Report from Martin Storr, MD, PhD: Functional Gastrointestinal Disorders: New Insights in Enteric Regulation
Report From Miguel Saps, MD: Functional Abdominal Pain in Children and Adolescents
2007 Award Recipients
Report from Bruce D. Naliboff, PhD: Symptom Based Psychology for Functional Gastrointestinal Disorders
Report from Magnus Simrén, MD, PhD: Irritable Bowel Syndrome: Searching for Underlying Causes
Report from Brennan M. R. Spiegel, MD, MSHS: Diagnostic Testing in Irritable Bowel Syndrome: Theory vs. Reality
Report from Sylvie Bradesi, PhD: Role of the Central Immune System in Functional Disorders
Paul E. Hyman, MD
Report from Miranda A. L. van Tilburg, PhD: Home Based Guided Imagery to Treat Pediatric Functional Abdominal Pain
Report from Fernando Azpiroz, MD, PhD: Understanding Intestinal Gas
2005 Award Recipients
Report from Yvette Tache, PhD: Stress and Irritable Bowel Syndrome: Unraveling the Code
Report from Shaheen Hamdy, MRCP, PhD: Adult Neurogenic Dysphagia -- Disorders and Conditions that Disrupt Swallowing
Report from Michael A. Pezzone, MD, PhD: Chronic Pelvic Pain and the Overlap of Pelvic Pain Disorders
Report from Bridget R. Southwell, PhD: Research into Treatment-Resistant Constipation in Children
Report from Rachel Rosen, MD, MPH: Symptoms Arising from Non-Acid Reflux in Children
2003 Award Recipients
Report from William E. Whitehead, PhD: Summary of Clinical Research Activities
Jyoti N. Sengupta, PhD
Report from Caroline Elder Danda, PhD: Biopsychosocial Perspectives on Assessment and Treatment
Report from Terry Buchmiller-Crair, MD: Using the Fetal Gastrointestinal Tract to Overcome Neonatal Disease
Report from Dan L. Dumitrascu, MD, PhD: The Psychosocial Adjustment to Illness in Irritable Bowel Syndrome
Report from Klaus Bielefeldt, MD, PhD: Understanding Pain and Discomfort in Functional GI Disorders
Research Grants
IFFGD Competitive Grants
2014 IFFGD Idiopathic Gastroparesis Research Grants
Leo Cheng, PhD
Braden Kuo, MD, MSc
Richard McCallum, MD
2008 IFFGD Competitive Research Grants
IFFGD Noncompetitive Grants
Other Research Grant Opportunities
Funding Research
Need for Funding Research
How to Make a Difference
The State of Research at NIH & NIDDK
Clinical Trials & Studies
Guide to Randomized Clinical Trials
Clinical Trials and Studies

Funding Research

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